DNA damage and repair in oncogenic transformation by heavy ion radiation.

Energetic heavy ions are present in galactic cosmic rays and solar particle events. One of the most important late effects in risk assessment is carcinogenesis. We have studied the carcinogenic effects of heavy ions at the cellular and molecular levels and have obtained quantitative data on dose-response curves and on the repair of oncogenic lesions for heavy particles with various charges and energies. Studies with repair inhibitors and restriction endonucleases indicated that for oncogenic transformation DNA is the primary target. Results from heavy ion experiments showed that the cross section increased with LET and reached a maximum value of about 0.02 micrometer2 at about 500 keV/micrometer. This limited size of cross section suggests that only a fraction of cellular genomic DNA is important in radiogenic transformation. Free radical scavengers, such as DMSO, do not give any effect on induction of oncogenic transformation by 600 MeV/u iron particles, suggesting most oncogenic damage induced by high-LET heavy ions is through direct action. Repair studies with stationary phase cells showed that the amount of reparable oncogenic lesions decreased with an increase of LET and that heavy ions with LET greater than 200 keV/micrometer produced only irreparable oncogenic damage. An enhancement effect for oncogenic transformation was observed in cells irradiated by low-dose-rate argon ions (400 MeV/u; 120 keV/micrometer). Chromosomal aberrations, such as translocation and deletion, but not sister chromatid exchange, are essential for heavy-ion-induced oncogenic transformation. The basic mechanism(s) of misrepair of DNA damage, which form oncogenic lesions, is unknown.     

高速低压差分信号（LVDS）器件应用设计方法研究

随着高速LVDS器件得到广泛应用，在高速信号使用LVDS传输时，信号传输线路问题、信号传输波形的最佳化成为非常重要的课题之一。由于印制电路板的布局布线直接影响信号传输质量，因此利用仿真对印制板分析成为设计上不可缺少的手段。有鉴于此，文章深入探讨了高速电路的设计，总结出设计技巧。     

飞机燃油油量测量及姿态误差修正方法

提出了一种基于 CAD技术的航空燃油油量实时测量方法。采用三维实体造型技术 ,建立了某飞机机翼油箱模型 ,利用油量传感器的输出值及飞机姿态信息 ,对燃油油量进行实时测量及姿态误差修正。     

飞机选型的模糊评判

本文把模糊数学的模糊变换原理用于购买新机型的评判。给出了各评判指标的定义和隶属度:并按 Saatz 的二元对比标度确定各指标的重要度;以及模糊变换的计算方法和应用举例。     

基于产品结构对设计文件进行有效管理

介绍了中国西南电子设备研究所设计文件管理平台——图档管理系统的特点、组成和功能,阐述了图档管理系统对文件管理的作用和意义,说明基于产品结构对设计文件进行管理的必要性和可行性。     

复合材料层板中就位横向拉伸强度的研究

本文利用弹性力学和断裂力学方法对纤维增强复合材料的横向拉伸强度进行了分析，其中考虑了９０度开裂层厚度和开裂邻层的约束效应的影响，推导出正交各向异性对称铺层中昨合就位横向拉伸强度的数学表达式，得出开裂层的厚度和约束邻层铺设角对就位横向拉伸强度都有影响的结论，理论计算与Ｆｌａｇｇｓ实验结果吻合较好。     

Organizing space cooperation in the Asia-Pacific region

The time for regional cooperation in the Asia-Pacific region is now ripe. Steps have been taken towards this via a workshop sponsored by China - previously wary of cooperation but now seeming to acknowledge that, along with interested countries, it could contribute more to space in the region. The author examines areas of shared interest over which parties might collaborate and the best way to achieve this: a gradual approach emulating the development (but not the present configuration) of ESA is recommended. Finally, he examines the legal framework within which cooperation might function, using a liaison committee to formulate and coordiante proposals. Action must be taken now if the region is not to fall behind in the development of space technologies.     

阻尼材料在飞机炮振减振上的应用

阻尼材料在飞机结构上的应用是一个新课题。在飞机炮舱区应用新型阻尼材料,组成一个全新的阻尼结构系统来吸收由航炮射击时产生的冲击能量,以实现减振的设计目的,进而改善其炮击的振动环境。通过理论计算和地面试验实测,证明了应用新型阻尼材料可使炮舱区的动应力下降近30％。     

水平冲量作用下共面椭圆轨道上航天器的交会

本文研究了在三次水平冲量作用下,一般共面椭圆轨道上两个航天器的固定时间交会问题。推导了完成交会的必要条件,给出了三次水平冲量的大小及其作用时刻的计算方法。     

VO2薄膜制备工艺及电阻开关特性研究

用溶胶－凝胶法在非晶玻璃上制备VO2薄膜，经过熔融、涂膜、烘干和热处理等工艺最后得到电阻相变2－3个量级的VO2薄膜。对烘干温度、熔融温度、膜厚和热处理温度对薄膜电阻开关特性的影响进行了研究。通过XRD（X－ray diffraction)和XPS（X－ray photoelectron spectroscopy）对薄膜的结构和价态进行分析，表明用溶胶－凝胶法制图VO2膜工艺简单，重复性好。